Low-chlorine Vs High-chlorine Crystalloids in Septic Shock Adults
Status:
Not yet recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
Fluid resuscitation is an important treatment in septic shock patients, however whether
crystalloid composition affects septic shock patients outcomes remains unclear. According to
previous studies, low-chlorine crystalloids could significantly reduce the incidence of
kidney injury and 30-day mortality compared with high-chlorine crystalloids in critically ill
adults. Therefore, we hypothesized that the use of low-chlorine crystalloids would result in
a lower incidence of major adverse kidney events within 30 days (MAKE 30: overall incidence
of death, new renal-replacement therapy, and persistent renal dysfunction) than high-chlorine
crystalloids in septic shock adults.