Low Sulfur Fecal Transplant for Ulcerative Colitis
Status:
Recruiting
Trial end date:
2023-12-31
Target enrollment:
Participant gender:
Summary
The purpose of this study is to evaluate the engraftment of donor microbiota's sulfate
reducing bacteria (SRB) in subjects with active ulcerative colitis (UC) following sequential
fecal microbiota transplant (FMT). Specifically this study will evaluate if low SRB donor
microbiota translates to lower SRB microbiota in the UC recipient. It is widely unknown if
the microbiota in UC is dysfunctional and therefore perpetuates inflammation, or if the
ongoing inflammation shapes the microbiota. Patients with UC have a higher relative abundance
of SRB compared to healthy controls. It is the aim of this study to determine if the
microbiota in UC can be altered to favor a low SRB fraction.
Phase:
Phase 1
Details
Lead Sponsor:
University of Minnesota University of Minnesota - Clinical and Translational Science Institute