Low Molecular Weight Heparin vs Unfractionated Heparin at Cardiac Surgery
Status:
Completed
Trial end date:
2005-05-01
Target enrollment:
Participant gender:
Summary
Because the impairment of platelet function may cause excess peri-operative bleeding,
pre-operative aspirin discontinuation and heparin bridging are common at cardiac surgery. We
aimed to evaluate the impact of a low-molecular-weight-heparin (LMWH), enoxaparin, and
unfractionated heparin (UFH) on coagulation parameters and peri-operative bleeding in
patients undergoing elective coronary artery bypass grafting (CABG) surgery after aspirin
discontinuation.
The specific hypothesis of this study was that a 12 h interval is sufficient not to cause
excess peri-operative bleeding, and is therefore an optimal compromise between antithrombotic
efficacy and haemorrhagic safety.