Overview

Low Dose of Sugammadex vs Neostigmine and Glycopyrrolate for the Reversal of Rocuronium

Status:
Recruiting

Trial end date:
2023-11-01

Target enrollment:
0

Participant gender:
All

Summary

The aim of this study is to compare the use of a low dose sugammadex and neostigmine combined to glycopyrrolate to reverse a rocuronium induced moderate neuromuscular blockade.

Phase:

Phase 4

Accepts Healthy Volunteers?

Accepts Healthy Volunteers

Details

Lead Sponsor:

Ciusss de L'Est de l'Île de Montréal

Treatments:

Glycopyrrolate
Neostigmine

Criteria

Inclusion Criteria:

- ASA 1-3 patients,

- Undergoing general anesthesia with rocuronium induced NMB,

- TOF 1-3 at the end of surgery,

- BMI < 36 kg.m-2,

- Age > 18 years old

Exclusion Criteria:

- History of coronary artery disease and unstable before surgery

- History of serious cardiac arrhythmia (including atrial fibrillation)

- Renal or hepatic dysfunction

- Obstructive sleep apnea requiring continuous positive airway pressure (CPAP) machine

- Neuromuscular disease

- Allergy to any drug used in the study protocol