Low Dose Peri-operative IV Ketamine for Chronic Post-surgery Pain Prevention
Status:
Completed
Trial end date:
2015-07-01
Target enrollment:
Participant gender:
Summary
This study will test the null hypothesis that low-dose ketamine given peri-operatively will
have no effect on the development of chronic post-surgical pain, in patients undergoing
thoracotomy or video assisted thoracic surgery (VATS) procedures
A double-blind, randomised placebo-controlled trial will be used to test the null hypothesis.
Potential participants due to undergo either thoracotomy or video assisted thoracic surgery
(VATS) will be identified by the collaborating thoracic surgeons in the out-patient
department. Patients will be sent information about the study by post, prior to admission for
surgery. If they are willing to participate, written consent will be sought on the ward
preoperatively, where they will complete baseline measures of pain.
Patients will be randomised to receive an intravenous infusion of placebo (saline) or
ketamine running at 0.1mg/kg/hour, starting 10 minutes prior to the surgical incision and
continuing for the first three postoperative days (96 hours in total). Prior to starting the
infusion a loading dose of ketamine (0.1 mg per kg) will be administered.
Phase:
Phase 4
Details
Lead Sponsor:
Imperial College Healthcare NHS Trust
Collaborator:
National Institute for Health Research, United Kingdom