Many patients with Postural Orthostatic Tachycardia Syndrome (POTS) experience debilitating
fatigue and this significantly impacts their daily lives. Unfortunately, there are no
treatments to help POTS patients with their fatigue. One medication, called low dose
naltrexone (LDN), has been tested as a treatment for fatigue in other medical conditions. In
this other research, LDN helped patients feel less fatigue. Other research studies have shown
that LDN can help reduce markers of inflammation called cytokines. Reducing these cytokines
could help reduce symptoms as well. There have been no research studies testing LDN in POTS
to date. We are planning to do a research study to test LDN as a treatment to see if it helps
POTS patients feel less fatigue.