Low Dose Morphine to Relieve Dyspnea in Acute Respiratory Failure (OPIDYS)
Status:
Recruiting
Trial end date:
2021-12-19
Target enrollment:
Participant gender:
Summary
This study evaluates a pharmacological intervention to relieve dyspnea in intensive care unit
patients. Indeed, opioids can be particularly beneficial since 1) dyspnea and pain share many
similarities, 2) the benefit of opioids on dyspnea has been clearly demonstrated in other
populations. However, to date, data regarding the impact of morphine on dyspnea in intensive
care unit patients admitted for acute respiratory failure are scarce. There may be a
reluctance of physicians to prescribe opioids that is not scientifically justified.
The study will focus on patient reported outcome (PRO) criteria. The ultimate goal of this
pilot study is to design the protocol of a future pragmatic trial.