Low Dose Aspirin in the Prevention of Preeclampsia in China

• Status: Completed
• Trial end date: 2019-03-30
• Target enrollment: 0
• Participant gender: Female

Summary

Preeclampsia is one of the three leading causes of maternal morbidity and mortality all over the world. The use of low dose aspirin has been mentioned in several studies with promising results. The investigators decided to evaluate the use of low dose aspirin in Chinese pregnant women, starting between 12+ and 20 weeks of pregnancy, based on clinical characteristics aiming to reduce the incidence of preeclampsia.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking University First Hospital
• Treatments: Aspirin; Salicylates; Salicylic Acid

Criteria

Inclusion Criteria:

1. Gestational age between 12+ and 20 weeks of pregnancy

2. High risk of preeclampsia, based in clinical risk factors as:

2.1 if they have one or more of the following risk factors： Preeclampsia in a previous pregnancy ,Diabetes Mellitus(Type 1 or 2),Chronic Hypertension .

2.2 if they have two or more of the following risk factors: Pre-pregnancy Body Mass Index ≥28kg/m2, Elderly pregnancy(age ≥35 years), Mother or sisters with preeclampsia in a previous pregnancy, Primiparity or Famliy history (Mother or sister that developed preeclampsia in a previous pregnancy）.

3. Signed informed consent.

Exclusion Criteria:

1. Allergy to aspirin

2. Asthma

3. Peptic ulcers

4. Severe heart, liver, renal disease who can not burden the experiment

5. Rheumatic immune disease

6. Mental disease

7. Alcohol and drug abuse

8. Being in another drug experiment within 3 months

9. Difficult to follow-up