Losartan in Hypertensive Men and Women With Sleep Apnea Before and on Continuous Positive Airway Pressure (CPAP) Treatment
Status:
Completed
Trial end date:
2014-02-01
Target enrollment:
Participant gender:
Summary
Obstructive sleep apnea (OSA) is a highly prevalent condition in hypertensive patients. The
renin-angiotension-aldosterone-system (RAAS) has a central role in blood pressure control. An
angiotensin-II-antagonist, Losartan, is an effective antihypertensive drug. However, some
patients respond to this drug worse than the others, and it is a clinical praxis to either
increase the dosage and/or add another drug. There is limited data regarding the impact of
antihypertensive drugs in OSA patients, i.e., whether or not OSA may constitute the subgroup
of therapy-resistent hypertensive patients. In the literature, there is no data, either,
whether or not CPAP treatment may have an additive blood pressure lowering impact in this
certain subgroup.