Losartan Versus Hydrochlorothiazide in Reversing Remodeling of Small Arteries in Pre-Hypertensive Pre-Diabetic Subjects
Status:
Terminated
Trial end date:
2009-12-01
Target enrollment:
Participant gender:
Summary
This randomized, double-blind, parallel group, two-centre pilot study will test the
hypothesis that subjects who are otherwise healthy but fulfill the criteria for a diagnosis
of pre-hypertension and pre-diabetes will have regression or reduced progression of
hypertension-associated changes in their resistance arteries if their blood pressure is
controlled for 6 months with losartan, whereas similar subjects whose blood pressure is
equally well controlled using hydrochlorothiazide will have significantly less improvement of
the changes in their resistance arteries.