Losartan/Amlodipine on Hemodynamics Parameters and Arterial Stiffness in Arterial Hypertension
Status:
Unknown status
Trial end date:
2019-06-14
Target enrollment:
Participant gender:
Summary
Systemic Arterial Hypertension (SAH) is a disease with a high prevalence in Mexico and
worldwide. SAH is associated with an increase in cardiovascular morbidity and mortality,
causing cardiovascular disease (CVD), heart failure (HF), as well as chronic kidney disease
(CKD). Several of the physiopathological mechanisms observed are: the increase in cardiac
output, central aortic pressure (CAP), pulse wave velocity (PWV) and peripheral vascular
resistance (PVR), which leads to the generation of damage to the target organ. The
identification not only of the peripheral arterial pressure, but also of these hemodynamic
parameters and arterial stiffness would allow a better cardiovascular characterization of the
patients. However, the measurements of hemodynamic parameters and arterial stiffness can vary
during the 24 hours from individual to individual by all known mechanisms involved in the
regulation of blood pressure such as cortisol, central nervous system, the peripheral nervous
system, along with the renin angiotensin and aldosterone system, which are usually only
measured in a single moment. Generally, the choice of drug in a patient with SAH is based
only on the values of peripheral blood pressure at the time of the measurement. The use of
oscillometric equipment such as the Mobil-O-Graph 24 allows to the investigators to know the
hemodynamic and arterial stiffness behavior during 24 hours; therefore, this could favor the
choice of the most appropriate antihypertensive drug, dose and administration time. The use
of angiotensin II receptor antagonists (ARA II) At1 blockers such as losartan and calcium
channel blockers (CCB) for instance amlodipine have shown a reduction in CAP and peripheral
blood pressure respectively in patients with SAH. The most prescribed drugs in health units
worldwide are enalapril, amlodipine, losartan and atenolol, of which the most used
combination is losartan with amlodipine. There are no studies to date that allow
investigators to identify the effect of the administration of losartan / amlodipine in a
fixed combination form on the hemodynamic parameters and arterial stiffness of patients with
SAH. Therefore, the objective of the present study is to evaluate the effect of this fixed
combination versus losartan on hemodynamic and arterial stiffness parameters based on the
behavior of these for 24 hours.
Phase:
Phase 4
Details
Lead Sponsor:
Centro Universitario de Ciencias de la Salud, Mexico