Longitudinal Study on the Neuroprotective and Neurotrophic Effects of Lithium

• Status: Completed
• Trial end date: 2012-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Thirty subjects with a DSM-IV (Diagnostic and Statistical Manual, fourth version)diagnosis of BPD during a depressive or hypomanic episode will be divided in two groups according to age and time of illness. All patients will receive lithium (flexible therapeutic dose) for 6 weeks and improvement will be evaluated weekly using depression and mania rating scales; this study also objectives to identify state/trait markers and predictors of response.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Sao Paulo
• Treatments: Lithium Carbonate

Criteria

Inclusion Criteria:

• outpatients

• 18-45 yo

• DSM-IV diagnosis of bipolar disorder (BD-I or BD-II)

• current depressive episode based on the Structured Clinical Interview for the Diagnostic and Statistical Manual for Mental Disorders(SCID-I)

• Hamilton Depression Rating Scale Score (HAM-D) ≥18

Exclusion Criteria

• Medical and psychiatric Comorbidity

• more than 5 years of disease duration

• presence of rapid cycling