The purpose of this study is to compare different ways of treating uncomplicated malaria in a
group of Ugandan children. The study will be divided into 2 parts. Part 1 of the study will
consist of 600 children, ages 1-10, living in the Mulago III Parish of Kampala. Approximately
90 children living in the same household as children from the Phase 1 portion of the study
will be enrolled in Phase II of this study. Participants in Phase II of the study will
receive an insecticide treated net to cover their bed. Over the course of the study,
participants will be tested for malaria when they present to the clinic with a fever or
illness. Participants that test positive for malaria will be given 1 of 3 possible study drug
combinations. Study procedures will include physical exams and blood samples. Children will
participate for about 3 years. Protocol 05-0110 is a study related to this protocol.
Phase:
Phase 3
Details
Lead Sponsor:
University of California, San Francisco
Collaborator:
National Institute of Allergy and Infectious Diseases (NIAID)
Treatments:
Amodiaquine Amodiaquine, artesunate drug combination Antimalarials Artemether Artemether-lumefantrine combination Artemether, Lumefantrine Drug Combination Artemisinins Artesunate Lumefantrine Pyrimethamine Sulfadoxine