Long-term Use of Proton Pump Inhibitors May Cause Vitamin B12 Deficiency in the Institutionalized Elderly

• Status: Completed
• Trial end date: 2008-04-01
• Target enrollment: 0
• Participant gender: All

Summary

This study was designed to determine whether elderly residents of long term care facilitated who had been taking proton pump inhibitors (PPI) for more than 12 months were more likely to have vitamin B12 deficiency than residents not taking PPI, and whether cyanocobalamin nasal spray improved these subjects' vitamin B12 status.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Delaware
• Treatments: Hydroxocobalamin; Proton Pump Inhibitors; Vitamin B 12; Vitamin B Complex; Vitamins

Criteria

Inclusion Criteria:

• age 60-89 years

• PPI use for >12 months (PPI group)

• no PPI use for 30 days prior to arm 1

• long term care resident

Exclusion Criteria:

• pernicious anemia

• severe megaloblastic anemia

• free-living

• serum creatinine > 1.8 mg/dL