Long-term Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD) With Venglustat
Status:
Terminated
Trial end date:
2021-07-13
Target enrollment:
Participant gender:
Summary
Primary Objective:
-To determine the effect of early versus delayed treatment with venglustat on the total
kidney volume (TKV) in participants at risk of rapidly progressive ADPKD.
Secondary Objective:
- To determine the effect of early versus delayed treatment with venglustat on the renal
function (estimated glomerular filtration rate [eGFR]).
- To characterize the safety profile of venglustat.
- To evaluate the effect of venglustat on the lens by ophthalmological examination.
- To evaluate the effect of venglustat on mood using Beck Depression Inventory-II
(BDI-II).