Overview

Long-Term Sulfonylurea Response in KCNJ11 Neonatal Diabetes

Status:
Completed
Trial end date:
2016-08-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to investigate long term response of sulfonylurea and glucose control in children with diabetes due to mutations in KCNJ11 that have been switched from insulin injections to sulfonylurea tablets.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Haukeland University Hospital
Collaborators:
Hôpital Necker-Enfants Malades
Institut National de la Santé Et de la Recherche Médicale, France
Royal Devon and Exeter NHS Foundation Trust
University of Bergen
University of Exeter
University of Rome Tor Vergata
Treatments:
Glyburide
Criteria
Inclusion Criteria:

- Permanent diabetes due to a mutation in KCNJ11 (KIR6.2)

- Patients successfully transferred from insulin to sulfonylurea

- Transferred to sulfonylurea treatment before November 1, 2006 (ie 9 years off insulin)

- Willing and able to provide informed consent (parents if younger than 16 years of age)

Exclusion Criteria:

- Permanent diabetes not due to a mutation in KCNJ11 (KIR6.2)

- Patients not successfully transferred from insulin to sulfonylurea

- Transferred to sulfonylurea treatment after November 1, 2006 (ie less than 9 years off
insulin)

- Not willing or able to provide informed consent (parents if younger than 16 years of
age)