Long-Term Lead Chelation Therapy and Progressive Renal Insufficiency
Status:
Completed
Trial end date:
2005-10-01
Target enrollment:
Participant gender:
Summary
Previous study showed repeated lead chelation therapy significant reduced progressive renal
insufficiency in patients with chronic renal diseases and high-normal body lead burden in a
placebo-controlled, randomized, 2-year clinical trial, even factors that influence
progression, such as blood pressure, the presence or absence of hyperlipidemia, and urinary
protein excretion were well controlled.Since relative small sample size and short duration of
follow-up were noted in the previous study, whether repeated lead chelation therapy could
long-term retard the progression of renal insufficiency remains unknown. Hence, we conducted
a 51-month placebo-controlled clinical trial to assess the long-term effect of repeated
chelation in progressive renal insufficiency of patients with high-normal body lead burden.