Long-Term Effects of Amantadine in Parkinsonian (AMANDYSK)
Status:
Completed
Trial end date:
2011-01-01
Target enrollment:
Participant gender:
Summary
This is a French national trial, conducted using a double-blind, placebo-controlled,
randomised design involving 7 centers and 80 patients of both sexes.
The primary objective of the trial is to evaluate the effects of the interruption of a long
term treatment (ex. Greater than 6 months) with Amantadine (prescribed as an antidyskinetic)
in patients suffering from Parkinson disease being treated with Levodopa and suffering from
mid dose dyskinesias.
Secondary objectives of the trial are the evaluation of the other effects of withdrawal of
Amantadine on the same group of patients: motor fluctuations, vigilance, apathy, fatigue,
certain cognitive aspects, the disappearance or development of undesirable side effects and
quality of life.