Overview

Locally Delivered Atorvastatin & Rosuvastatin for Treatment of Furcation Defects in Chronic Periodontitis

Status:
Completed
Trial end date:
2016-02-01
Target enrollment:
0
Participant gender:
All
Summary
Statins are one of the lipid lowering drugs that help in reducing cholesterol levels in the body by specifically inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase; which is a rate limiting enzyme for cholesterol synthesis. Rosuvastatin (RSV) and atorvastatin (ATV) have shown to have bone stimulatory and anti-inflammatory effects.. The present study aims to explore the efficacy of 1.2% RSV and 1.2% ATV gel as a local drug delivery and redelivery system as an adjunct to scaling and root planing (SRP) for the treatment of degree II furcation defects.
Phase:
Phase 2/Phase 3
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Government Dental College and Research Institute, Bangalore
Treatments:
Atorvastatin
Atorvastatin Calcium
Rosuvastatin Calcium
Criteria
Inclusion Criteria:

- Systemically healthy patients with mandibular class II furcation defects and
asymptomatic endodontically vital mandibular molars with radiolucency in furcation
area with PD ≥ 5mm and horizontal PD ≥ 3mm and with no history of antibiotic or any
periodontal therapy in past 6 months were included in the study

Exclusion Criteria:

- Subjects with any known systemic disease, allergic to statins, on systemic statin
therapy, alcoholics, tobacco users, pregnant or lactating women