Locally Applied Antibiotics for Infection Prophylaxis in Treatment of Open Fractures
Status:
Unknown status
Trial end date:
2020-07-01
Target enrollment:
Participant gender:
Summary
The primary objective of this study is to investigate the effectiveness of local antibiotic
versus placebo in the prevention of infections in open fractures. The study will assess
whether local treatment of open fractures with the antibiotic tobramycin (in addition to
standard systemic antibiotics) will decrease the risk and rate of infection, and rate of
re-operation. This will be studied using a randomized controlled clinical trial design in
adult population of age 18-70 years who present with open fractures. About 133 subjects will
be recruited in this study at UVA.