Local Vasoconstriction in Postural Tachycardia Syndrome
Status:
Completed
Trial end date:
2015-06-01
Target enrollment:
Participant gender:
Summary
The investigators study will determine how often blood flow regulation abnormalities and
abnormalities of sympathetic regulation produced by nitric oxide, angiotensin-II, and
oxidative stress occur in POTS and the mechanism(s) of POTS in individual patients. Specific
causes for POTS may vary from patient to patient. Patients will be compared to healthy
control subjects. There is a treatment arm with a medication (losartan) that reduces the
binding of angiotensin and increases NO. If the investigators know the specific biochemical
mechanism the investigators may be able to offer further specific treatments to specific
patients.