Local Minocycline in Patients Under Supportive Periodontal Therapy
Status:
Completed
Trial end date:
2019-10-18
Target enrollment:
Participant gender:
Summary
The aims of the present study are to assess the significance of the adjunctive effect of the
subgingival application of a 2% minocycline hydrochloride controlled-delivery system (MHS) in
comparison to subgingival instrumentation with application of a placebo gel, 3 months after
therapy in subjects with recurrent periodontitis undergoing supportive periodontal therapy
(SPT) and to assess the substantivity of the gel attributable to the adjunctive delivery of
the medication that is detected at 3 months during a 9-month period of regular SPT. Recurrent
periodontitis will be defined as sites with residual periodontal probing depths and bleeding
on probing after completion of initial periodontal therapy. This will include both persistent
and recurrent periodontitis, where persistent means the residual periodontal site after
initial periodontal therapy, and recurrent means the site which was improved by initial
periodontal therapy, but disease recurred.