Local Infiltration With Ropivacaine Improves Postoperative Pain Control in Patients

• Status: Completed
• Trial end date: 2017-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the effect of pain relief after infusion of ropivacaine at port sites at end of laparoscopic cholecystectomy (LC)compared with placebo (0.9% normal saline).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Air Force Military Medical University, China; Fourth Military Medical University
• Treatments: Ropivacaine

Criteria

Inclusion Criteria:

• Female or male, and any race, Age≥18 years at the screening visite.

• ASA physical status I to II.

• Scheduled to undergo laparoscopic cholecystectomy under general anesthesia.

• Famale subjects must be without pregnancy.

• Ability to provide informed consent, adhere to the study visite schedule, and complete all study assessments.

Exclusion Criteria:

• Boss mass index >35kg/㎡

• Under intravertebral anesthesia and/or epidural analgesia

• Under postoperatived patient-controlled epidural analgesia (PCEA) and postoperative intravenous analgesia(PCIA).

• Inability to understand and use the visual analog scale (VAS)

• Currently pregnant,nursing,or planning to become pregnant during the study or within one month after study drug administration.

• Chronic user of analgesic medications, including taking opioid medications for more than 14 days in the last 3months,or non-opioid pain medications more than 5 times per week.

• Proven or suspected allergy to local anesthetics ,NSAIDs and opioids .

• Use of any NSAIDs including selective COX-2 inhibitor , opioids or other analgesic agents within 3days of surgery.

• History of suspected or known addiction to or abuse of drugs or alcohol within the past 2 years.

• Current acute or chronic medical or major psychiatric disease that,in the opinion of the investigator ,would interfere with the evaluation of study drug efficacy or safety.

• Any other subjects were not suitable to this study in the opinion of the investigator.