Local Anesthetic Treatments for Overactive Bladder

• Status: Terminated
• Trial end date: 2010-05-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to determine whether alkalized lidocaine instilled into the bladder is effective in the treatment of overactive bladder (OAB).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Frank F. Tu; Frank Tu
• Collaborator: Berlex Foundation
• Treatments: Anesthetics; Lidocaine

Criteria

Inclusion criteria:

• Female patient, 18 years of age and older

• Overactive bladder defined as:

• Urinary frequency defined as eight or more voids in a 24 hour period > 50% of days of the week

• Symptoms of urgency

• Symptoms of at least three months duration

Exclusion criteria:

• Positive urine culture in the past month, or more than 3 episodes of bladder infection in the last 2 months

• Stress or overflow urinary incontinence (determined by clinician) if more than 14 episodes of urinary incontinence per week; also insensate incontinence

• Pregnancy

• Seizure disorder or clinically significant renal disease, allergy to lidocaine, uninvestigated hematuria, or history of urinary/reproductive tract malignancy

• Post-void residual more than 200 cc