Overview
Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers
Status:
Recruiting
Recruiting
Trial end date:
2025-06-01
2025-06-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
Local anesthetic resistance is commonly reported by patients with EDS. However, there are no objective data on the occurrence of local anesthetic resistance in EDS patients and in healthy volunteers. The investigators propose to collect such objective data on the frequency of drug resistance and whether any problems with local anesthesia are due to initial ineffectiveness or due to its effects dissipating too soon.Phase:
Phase 4Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
University of CalgaryCollaborator:
Vanderbilt University Medical CenterTreatments:
Bupivacaine
Lidocaine
Criteria
Inclusion Criteria:- EDS patients, clinically diagnosed hypermobile EDS based on 2017 criteria
- EDS patients with genetically proven non-hypermobile EDS
- Healthy participants, no EDS
- Able and willing to provide informed consent
Exclusion Criteria:
- Known allergy to Lidocaine or Bupivacaine
- Unable to provide informed consent