Local Anesthesia Versus Saline Serum in Surgical Incision of Colorectal or Hepatic Surgery

• Status: Completed
• Trial end date: 2014-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether a continuous infusion of local anesthesia with a catheter in the surgical wound reduces patient consumption of opiates by 30% in the 48-hour postoperative period following surgery for colorectal neoplasm and hepatic surgery versus the continuous infusion of physiological serum.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital Universitari de Bellvitge
• Treatments: Anesthetics; Pharmaceutical Solutions; Ropivacaine

Criteria

Inclusion Criteria:

• ASA I-III

• Undergoing scheduled colorectal cancer and hepatic surgery

• Patients must be able to understand the PCA (the self administration system)

Exclusion Criteria:

• Background of allergic reaction or contraindication for local anesthesia or non steroid anti-inflammatory drugs.

• Patient with epidural catheter or receiving combined analgesia during surgery (age above 80, moderate-severe respiratory dysfunction, patients who prior presented complex postoperative pain management.

• Emergency surgery

• Patients with risk of hepatic insufficiency (Klatskin's tumor, extended right hepatectomy, right hepatectomy in patients with steatosis, hepatic resection in patients over 70 years of age who have been given chemotherapy).

• Inflammatory bowel disease: ulcerative colitis, Crohn's disease.

• Major psychiatric condition.

• Patients with active drug addiction or on chronic treatment with opiates.

• Morbid obesity (BMI > 35 kg/m2)

• Patients with heart disease (myocardiopathy, conduction alterations, antiarrhythmic treatment) and severe liver disease (alteration synthesis, histolysis and or cholestasis).

• Patients with kidney failure.

• Patients treated with fluvoxamine (antidepressant) and enoxacin (antibiotic) both are potent inhibitors of CYPIA2.

• Septic patients

• Patients that do not wish to participate.