Local Anaesthetic Effects of Transcutaneous Amitriptyline
Status:
Completed
Trial end date:
2007-12-01
Target enrollment:
Participant gender:
Summary
The aim of this study is to assess the local anaesthetic effects of amitriptyline applied on
the skin of human volunteers, considering the differential effects on mechanic and thermic
sensitivity, the local and general tolerance, and the systemic absorption of the drug. The
solution used for dilution of amitriptyline is the only one known to allow transcutaneous
absorption of the drug [1]. Considering that the peripheral sensitive fibre is a possible
site of action of tricyclic antidepressants for relieving neuropathic pain [2,3], this is a
first step study before further assessment of the therapeutic effects of transcutaneous
amitriptyline.
Phase:
Phase 1
Details
Lead Sponsor:
University Hospital, Clermont-Ferrand
Treatments:
Amitriptyline Amitriptyline, perphenazine drug combination Anesthetics Anesthetics, Local