Living With Statins - Interventional Exercise Study
Status:
Active, not recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
Background. Statins are cholesterol lowering drugs that are prescribed to lower the risk of
cardio-vascular diseases. The use of statins has increased markedly and it is now one of the
most prescribed drugs in the world. More than 600,000 people in Denmark are taking statins on
a daily basis, approximately 40 % of these are taking the medication without having any other
risk factors for cardio-vascular diseases than elevated blood-cholesterol i.e. they are in
primary prevention.
Statins are not without side effects and studies have shown that there is an elevated risk of
developing diabetes when taking statins. This has led to an increased debate about the use of
statins in primary prevention. Furthermore a large meta-analysis has shown that to prevent
one event of cardio-vascular disease, it is necessary to treat 200 people for 3-5 years.
These data suggest that more conservative use of statins to prevent CVD in otherwise healthy
individuals at low risk for future CVD may be warranted.
Other side effects of statins are muscle myalgia, muscle cramps and fatigue which potentially
can prevent a physically active lifestyle. The biomedical background of these side effects is
not fully elucidated but it has been shown that there is a link to decreasing levels of an
important enzyme, Q10, which plays a role in muscle energy metabolism.
Hypothesis
The overarching research question is: why does statin treatment cause muscle pain? Does
statin treatment impair (or even prohibit) physical exercise training? Furthermore the
following questions will be investigated:
A. Does statin treatment cause:
1. Decreased muscle strength?
2. Skeletal muscle inflammation?
3. Decreased mitochondrial respiratory function? B. Abnormal glucose homeostasis?
Re question A & B: If so, can physical training counteract this effect of statin treatment?