Liver and Fat Regulation in Overweight Adolescent Girls
Status:
Active, not recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
Women with polycystic ovarian syndrome (PCOS) have increased rates of hepatic steatosis
compared to weight similar women with regular menses. It is unclear if this is related to
high testosterone or insulin resistance. The investigators will assess hepatic glucose
release, rates of lipolysis and hepatic de novo lipogenesis in the fasted and postprandial
state to determine if alterations in the processes contribute to hepatic steatosis.
Participants will be overweight, sedentary girls with or without PCOS. Those with PCOS will
either be medication naive, or must be taking metformin or combined oral contraceptives
(COCPs) for a period of at least 6 months prior to study procedures.