Live Birth Rate Between PPOS and GnRH Antagonist Protocol in Patients With Anticipated High Ovarian Response
Status:
Recruiting
Trial end date:
2024-10-01
Target enrollment:
Participant gender:
Summary
Progestin can inhibit the pituitary LH surge during ovarian stimulation and various studies
show progestin-primed ovarian stimulation (PPOS) is effective in blocking the LH surge in
IVF. More and more centers in China are using PPOS because this regimen appears simpler and
cheaper.A randomized trial to compare the effectiveness of PPOS and GnRH antagonist protocol
in IVF in terms of the live birth rate is urgently needed.
Trial objectives: To compare the live birth rate between the PPOS protocol and the antagonist
protocol used for ovarian stimulation during IVF
Eligible women will be randomised into one of the two groups:
Antagonist group : Women will receive antagonist (Cetrorelix or Ganirelix 0.25mg) once
subcutaneously daily from day 6 of ovarian stimulation till the day of the ovulation trigger.
PPOS group: Women will receive oral medroxyprogesterone 10 mg daily or duphaston 10mg bd
daily from Day 3 till the day of ovulation trigger.
There will be no fresh transfer. Only one blastocyst will be allowed to replaced in the first
FET and a maximum of two blastocysts will be replaced in the subsequent FET cycles.
The primary outcome is the live birth rate of the first frozen-thawed transfer cycle.