Overview

Lithium, Cord Blood Cells and the Combination in the Treatment of Acute & Sub-acute Spinal Cord Injury

Status:
Completed
Trial end date:
2014-01-01
Target enrollment:
0
Participant gender:
All
Summary
The trial is to investigate the safety and efficacy of oral lithium, intraspinal umbilical cord blood mononuclear cell transplant, and the combination in the treatment of acute and subacute spinal cord injury
Phase:
Phase 1/Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
China Spinal Cord Injury Network
Collaborators:
Chengdu PLA General Hospital
StemCyte, Inc.
Treatments:
Lithium Carbonate
Criteria
Inclusion Criteria:

- either gender and 18-65 years old;

- acute or subacute traumatic spinal cord injury (defined as SCI resulting from an
exteneral non-penetrating cause that occurred within 4 weeks);

- neurological status of ASIA A;

- neurological level between C5-T11;

- MRI shows injury site is within 3 vertebral level and necrotic focus, if exist, is
less than 1/3 of the spinal cord diameter;

- professional judgment determinate that subjects need a spinal decompression surgery;

- subjects able to complete neurological examination;

- subjects have voluntarily signed and dated an informed consent form.

Exclusion Criteria:

- penetration SCI such as gun-shoot, knife-cutting or SCI caused by non-traumatic
conditions;

- spinal cord lesion exceeds three segments or necrotic focus with diameter larger than
1/3 of the spinal cord;

- severe complications;

- significant medical diseases or infection;

- pregnant or lactating woman, or female of childbearing potential and who is unwilling
to use an effective contraceptive method while enrolled in the study;

- unavailability of suitable umbilical cord blood cells;

- contraindication of lithium carbonate and/or spinal decompression surgery

- subject is currently participating in another study or has been taking any
investigational drug within the last 4 weeks prior to screening;

- investigator suggests that the subject would not be suitable to participate this study