Liposomal Bupivacaine vs Adductor Canal Block in Total Knee Arthroplasty

• Status: Completed
• Trial end date: 2019-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is being done to evaluate the outcomes of patients undergoing total knee replacement with two different methods of local pain control:shots of liposomal bupivacaine, a long acting anesthetic, directly into the knee during surgery or anesthetic delivered continuously to the adductor canal to provide long term pain relief. The goal is to try to find a standard protocol that provides the greatest pain relief for patients undergoing total knee replacement.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Texas Orthopaedics, Sports and Rehabilitation Associates
• Treatments: Anesthetics; Bupivacaine; Ropivacaine

Criteria

Inclusion Criteria:

• Male or non-pregnant female between the ages of 18-65

• Patients willing and able to sign the informed consent

• Patients able to comply with follow-up requirements including self-evaluations

• Patients requiring a primary total knee replacement

• Patients with a diagnosis of osteoarthritis, traumatic arthritis, or avascular necrosis

Exclusion Criteria:

• Revision total knee arthroplasty

• Bilateral total knee arthroplasty

• Patients with inflammatory arthritis

• Patients with a body mass index (BMI) > 40

• Allergy to ropivacaine, bupivacaine, or other local anesthetic agents

• Current use of opioid drugs

• Patients with a history of total or unicompartmental reconstruction of the affected joint

• Patients that have had a high tibial osteotomy or femoral osteotomy

• Patients with neuromuscular or neurosensory deficiency, which would limit the ability to assess pain levels

• Patients with a systemic or metabolic disorder leading to progressive bone deterioration

• Patients that are immunologically compromised, or receiving chronic steroids (>30 days), excluding inhalers

• Patients' bone stock is compromised by disease or infection, which cannot provide adequate support and/or fixation to the prosthesis

• Patients with knee fusion to the affected joint

• Patients with an active or suspected latent infection in or about the knee joint

• Patients that are prisoners