Overview

Liposomal Bupivacaine Intercostal Nerve Block vs Thoracic Epidural for Regional Analgesia in Multiple Rib Fractures

Status:
Recruiting
Trial end date:
2021-08-01
Target enrollment:
0
Participant gender:
All
Summary
Management of traumatic rib fractures continues to be a challenge for trauma surgeons. Currently, many analgesic options are available to patients suffering from rib fractures. Formulations currently used for conventional intercostal nerve blocks (CINB) are relatively safe, do not require additional equipment or specialized anesthesia personnel, do not require catheter repositioning, and provide improved analgesia immediately over the aforementioned systemic therapies. A goal of these authors to introduce an additional safe option for extended local analgesia in the setting of multiple rib fractures given the inconclusive evidence supporting or refuting the current standard of care
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Chadrick Evans
OSF Healthcare System
Collaborators:
OSF Healthcare System
University of Illinois College of Medicine at Peoria
Treatments:
Bupivacaine
Criteria
Inclusion Criteria:

- All patients 18 years of age or older suffering 3 or more rib fractures treated by
University of Illinois College of Medicine at Peoria (UICOMP) attending or resident
physicians at OSF St. Francis Medical Center (OSFMC) are potentially eligible for
enrollment in the trial.

Exclusion Criteria:

- Patients with any of the following will not be eligible since they are
contraindications to CEA, LBINB, or both:

1. Intracranial hemorrhage

2. Fever >101 degrees Fahrenheit for ≥ 1 hour(s)

3. Rash at site of catheter insertion or administration of nerve block

4. Hemodynamic instability

5. Spinal cord injury

6. Vertebral fractures

7. Allergy to bupivacaine

8. Systemic therapeutic anticoagulation required for duration of hospital admission
20

9. Altered mental status without medical decision maker to provide consent

10. Patients without the capacity to consent or the lack of a medical decision maker
to consent

11. Patients that are pregnant

12. Legally confined patients.