Lipid Biomarkers for Diabetic Heart Disease

• Status: Completed
• Trial end date: 2018-02-23
• Target enrollment: 0
• Participant gender: All

Summary

This study will test whether lowering the delivery of excess fats to the heart in persons with type-2 diabetes mellitus improves heart muscle function. The investigators will also test whether specific lipid molecular species in plasma can serve as biomarkers for diabetic heart disease.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Washington University School of Medicine
• Collaborators: Leducq Foundation; National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health (NIH)
• Treatments: Fenofibrate

Criteria

Inclusion Criteria:

• Type 2 diabetes mellitus

Exclusion Criteria:

• body weight > 300 lb.

• HIV

• hypothyroid

• steroid medication, fenofibrate

• smoking

• BP > 140/90

• heart disease

• pregnant or lactating

• consumption of > 5 alcoholic drinks/wk

• creatinine > 1.5 mg/dL

• hematocrit < 28