Liothyronine in Children With Single Ventricle Congenital Cardiac Malformations Undergoing the Fontan Procedure
Status:
Completed
Trial end date:
1997-12-01
Target enrollment:
Participant gender:
Summary
OBJECTIVES: I. Determine the pharmacokinetics of exogenous liothyronine administered in
children undergoing the modified Fontan procedure.
II. Determine the liothyronine supplementation dose that counters the fall in serum
liothyronine concentrations and provides the greatest potential myocardial benefit after the
modified Fontan procedure.
III. Evaluate the potential toxicity of exogenous liothyronine administered in children
undergoing a modified Fontan procedure.