Light, Ion, and Fluoxetine Efficacy (LIFE) in Depression
Status:
Completed
Trial end date:
2014-05-01
Target enrollment:
Participant gender:
Summary
This study will investigate the additional benefits of light and ion therapy as added
treatments to an antidepressant (fluoxetine) in subjects with major depressive disorder
(MDD), versus treatment with fluoxetine alone. Outcomes will include depressive symptom
rating scales and measures of quality of life, work absence and productivity, and use of
health care services. The primary hypotheses are that, in patients with nonseasonal major
depressive disorder (MDD) of at least moderate severity: 1) bright light therapy or negative
ion therapy will be superior to a placebo condition in reducing symptoms of depression, and
2) the combination of fluoxetine and either bright light or negative ion therapy is more
effective than either monotherapy condition.