Lidocaine on Manifestations of Fibromyalgia

• Status: Completed
• Trial end date: 2008-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Background and Objectives: Fibromyalgia is a pain syndrome characterized by numerous manifestations. The objective of this study was to evaluate the effect of the combination of intravenous lidocaine and amitriptyline on the manifestations of fibromyalgia. Methods: A prospective, randomized, double-blind, comparative study was conducted. All patient received 25 mg amitriptyline. Patients of group 1 (n = 15) received 125 mL 0.9% saline, and patients of group 2 (n = 15) received 240 mg lidocaine in 125 mL 0.9% saline once a week for 4 weeks. Manifestations were recorded before and 4 weeks after treatment. Pain intensity was rated on a verbal numerical scale.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Federal University of São Paulo
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

• pain in the four quadrants of the body for at least 3 months

• sleep disorders

• fatigue

• subjective edema

• depression

• paresthesia.

Exclusion Criteria:

• alterations in thyroid

• rheumatological

• renal and hepatic function

• trauma

• rheumatic, neuromuscular or psychiatric disease

• infectious arthropathy

• other pain syndromes

• drug hypersensitivity

• pregnancy