Lidocaine and Ketamine in Abdominal Surgery

• Status: Terminated
• Trial end date: 2012-07-01
• Target enrollment: 0
• Participant gender: Female

Summary

This study is being done to determine if combined infusions of lidocaine and ketamine is better than a lidocaine or ketamine infusion alone, or to placebo in improving recovery after abdominal hysterectomy. Participants will be randomized into one of four groups. Evaluations will be done through walking tests, pain and fatigue questionnaires and blood tests.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Outcomes Research Consortium; The Cleveland Clinic
• Treatments: Ketamine; Lidocaine

Criteria

Inclusion Criteria:

• Age greater than 18 years old and less than 75 years years old

• Horizontal abdominal incision

Exclusion Criteria:

• Emergency or urgent procedure

• Preexisting chronic pain (at any site) requiring treatment

• Contraindication to any study medication (ketamine or lidocaine)

• History of significant Axis I psychiatric disease (major depressive disorder, bipolar disorder, schizophrenia, etc.)

• Significant hepatic (ALT or AST > 2 times normal) or renal (serum creatinine > 2 mg/dl) impairment

• Seizure disorder requiring medication within past 2 years

• Planned spinal or epidural anesthesia or analgesia