Lexapro for the Treatment of Traumatic Brain Injury (TBI) Depression & Other Psychiatric Conditions

• Status: Completed
• Trial end date: 2013-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This research is being done to see if a drug called escitalopram (Lexapro) is helpful to people who are suffering from depression after traumatic brain injury (TBI).

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Johns Hopkins University
• Collaborator: Forest Laboratories
• Treatments: Citalopram; Dexetimide

Criteria

Inclusion Criteria:

• Closed head injury

• Fulfill Diagnostic and Statistical Manual Diploma in Social Medicine (DSM) IV criteria "Major Depressive Disorder"

• 18 years of age or older

• Able to provide informed consent

• Stable medical history

Exclusion Criteria:

• History of Stroke, Encephalitis, Seizures, or any other pre-TBI neurological diseases

• History of mental retardation

• Alcohol or Substance dependence in the last 1 year

• Inability to undergo MRI scan

• Pregnancy

• Current use of any psychotropic medications including any antidepressants, antipsychotics, anxiolytics, or sedative hypnotics

• Poor response to escitalopram in the past

• Acutely suicidal or requiring inpatient psychiatric hospitalization, as determined by the study psychiatrist

• Good medication response to another antidepressant in the past