Levothyroxine Replacement With Liquid Gel Capsules vs Tablets Post-thyroidectomy
Status:
Terminated
Trial end date:
2019-11-04
Target enrollment:
Participant gender:
Summary
In some patients, levothyroxine liquid gel capsules may demonstrate superior absorption than
the tablet option. Impaired absorption of thyroid hormone directly correlates to higher and
more unpredictable TSH (thyroid stimulating hormone) levels.
The investigators therefore hypothesize that following thyroidectomy for Stage I/II
differentiated thyroid cancer the gel capsule levothyroxine formulation will provide more
predictable TSH results and in turn require fewer dose adjustments to achieve optimal hormone
levels in the postoperative period.
The aim of this investigation is to compare the use of levothyroxine in liquid gel capsules
to tablet form for TSH suppression following thyroidectomy for presumed stage I/II
differentiated thyroid cancer.