Levocetirizine Effect on Nasal Nitric Oxide and Nasal Eosinophils in Subjects With Perennial Allergic Rhinitis

• Status: Completed
• Trial end date: 2009-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to noninvasively measure the anti-inflammatory effect of levocetirizine after two weeks of treatment in allergic rhinitis subjects.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: AAADRS Clinical Research Center
• Collaborator: UCB Pharma
• Treatments: Cetirizine; Levocetirizine; Nitric Oxide

Criteria

Inclusion Criteria:

• ICF signed

• Diagnosis of PAR for 6-12 months greater

• 12 years and older

• Decreased nasal NO values at baseline

• Compliance and ability to perform maneuvers and responsibilities

Exclusion Criteria:

• Oral or systemic steroids for 60 days prior

• Inhaled, nasal, nebulized steroids w/i 4 weeks

• Hospitalization or life threatening asthma

• Use of nasal or oral antihistamines w/i 4 weeks

• Upper or lower airways infection

• Direct cigarette smoke exposure