Leukotriene D4 Nasal Provocation Test in Allergic Rhinitis
Status:
Completed
Trial end date:
2014-04-01
Target enrollment:
Participant gender:
Summary
Leukotrienes play critical roles in the inflammatory process in allergic rhinitis and
bronchial asthma, therefore, anti-leukotriene therapy is part of treatment for asthma.
However, not all allergic rhinitis accompanied with or without asthma treated with
anti-leukotriene were effective. So it is critical to develop a method to identify the
response subgroup. In this study, it is assumed that nasal physiological responsiveness to
leukotriene nasal provocation test (NPT) is able to gain evidence on the effect of
leukotriene on the development of allergic rhinitis and asthma, and is helpful to the use of
anti-leukotriene agent. The purpose of the study is to establish the methodology and
diagnostic value of leukotriene D4 (LTD4) nasal provocation.