Leukotriene D4 Bronchial Provocation Test (LTD4-BPT) as an Indicator for the Use of Leukotriene Receptor Antagonist (LTRA)
Status:
Completed
Trial end date:
2010-09-01
Target enrollment:
Participant gender:
Summary
Background: Therapeutic outcomes of leukotriene receptor antagonist (LTRA) vary in
asthmatics，and there's not an ideal and simple way for prediction at present.
Objective：To investigate whether leukotriene D4 bronchial provocation test (LTD4-BPT) could
be an indicator of actual therapeutic outcome of LTRA.
Methods：A single centre, open-labeled trial was performed in 32 asthmatics with positive
LTD4-BPT result for a month. All subjects were categorized according to airway responsiveness
to leukotriene D4（PD20FEV1-LTD4）. Subjects received montelukast therapy (10mg, once per
night), and reassessment was performed (3~5) days after withholding LTRA. The primary
end-point was the difference in monthly PEFR. Secondary endpoints included the difference in
FENO, PD20FEV1-LTD4, PD20FEV1-MCh, pre-test FEV1, ACT score, AQLQ symptom score, week 4
PEFmax and PEFmin as compared with week 1, gradual decrease in the use of salbutamol and the
days without using salbutamol.