Letrozole vs Danazol for Endometriosis-Related Pain: Randomized Trial
Status:
COMPLETED
Trial end date:
2025-07-31
Target enrollment:
Participant gender:
Summary
Background:
Endometriosis is a chronic gynecological condition defined by the ectopic presence of endometrial glands and stroma outside the uterine cavity, most commonly diagnosed via laparoscopy. While its exact etiology remains uncertain, a positive family history is considered a significant risk factor. Danazol has historically demonstrated efficacy in alleviating endometriosis-related pain, while letrozole, primarily used in neoadjuvant settings, has recently emerged as a promising alternative. This study aimed to compare the mean reduction in pain scores between letrozole and danazol in women with laparoscopically confirmed endometriosis.
Objective:
To compare the efficacy of letrozole versus danazol in reducing pain scores among women diagnosed with endometriosis.
Material \& Methods:
Study Design: Randomized control trial Setting: Department of Obstetrics \& Gynaecology, Sharif Medical and Dental Hospital