Letrozole add-on in the Treatment of Cesarean Scar Pregnancy
Status:
Active, not recruiting
Trial end date:
2023-06-30
Target enrollment:
Participant gender:
Summary
It is hypothesized that the inhibition of estradiol production by letrozole may interfere
with physiological effects of progesterone necessary to maintain the pregnancy. There is no
reference treatment of cesarean scar pregnancy (CSP) as the limited number of cases precludes
the extrapolation of results. In our center we successfully use two-step treatment with
methotrexate (MTX) followed by hysteroscopic removal of products of conception (POC). The
time in between is needed to achieve a decrease in the trophoblast's vital potential (B-hCG
fall) and its vascularization. Additional administration of letrozole could further reduce
the vital potential of the pregnancy, eliminating the need for another dose of MTX, resulting
in faster healing and lower rate of complications.