Overview

Letrozole With or Without Paclitaxel and Carboplatin in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Status:
Recruiting
Trial end date:
2028-02-01
Target enrollment:
0
Participant gender:
Female
Summary
This phase III trial studies how well letrozole with or without paclitaxel and carboplatin works in treating patients with stage II-IV low-grade serous carcinoma of the ovary, fallopian tube, or peritoneum. Letrozole is an enzyme inhibitor that lowers the amount of estrogen made by the body which in turn may stop the growth of tumor cells that need estrogen to grow. Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving letrozole alone or in combination with paclitaxel and carboplatin works better in treating patients with low-grade serous carcinoma of the ovary, fallopian tube, or peritoneum compared to paclitaxel and carboplatin without letrozole.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
NRG Oncology
Collaborator:
National Cancer Institute (NCI)
Treatments:
Albumin-Bound Paclitaxel
Carboplatin
Letrozole
Paclitaxel
Criteria
Inclusion Criteria:

- Patients must have the psychological ability and general health that permits
completion of the study requirements and required follow up

- All women will, by definition, be considered menopausal due to surgical removal of
both ovaries prior to trial enrollment

- Patients must have newly diagnosed, stage II-IV low-grade serous ovarian cancer
(submission of pathology report[s] required). Ovarian cancer = ovarian, fallopian tube
and primary peritoneal cancers. p53 immunohistochemistry (IHC) is required and must
show nonaberrant pattern (nonaberrant p53 expression is consistent with
normal/wildtype TP53). If aberrant p53 expression is found on p53 IHC, the patient is
NOT eligible (aberrant p53 expression is consistent with mutant TP53 and supports
diagnosis of high grade serous ovarian cancer). A copy of the pathology report that
includes the diagnosis of low grade serous ovarian cancer and nonaberrant p53 IHC
result must be submitted in RAVE

- Appropriate stage for study entry based on the following diagnostic workup:

- History/physical examination within 14 days prior to registration

- Contrast-enhanced imaging of the chest, abdomen and pelvis within 28 days prior
to registration

- Patients must have undergone an attempt at maximal upfront cytoreductive surgery, with
either optimal (=< 1 cm diameter residual disease/nodule) or suboptimal residual
disease (> 1 cm diameter residual disease/nodule) status allowed

- Patients must have undergone a bilateral salpingo-oophorectomy

- Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of
0, 1 or 2 within 14 days prior to registration

- Patients must be within =< 8 weeks of primary cytoreductive surgery at time of
randomization

- Patients must be able to take per oral (P.O.) medications

- Absolute neutrophil count (ANC) greater than or equal to 1,500/mcl (within 14 days
prior to registration)

- Platelets greater than or equal to 100,000 cells/mcl (within 14 days prior to
registration)

- Creatinine less than or equal to 1.5 x upper limit of normal (ULN) (within 14 days
prior to registration)

- Bilirubin less than or equal to 1.5 x ULN (within 14 days prior to registration)

- Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) less than or equal
to 3 x ULN (within 14 days prior to registration)

- The patient or a legally authorized representative must provide study-specific
informed consent prior to study entry and, for patients treated in the United States
(U.S.), authorization permitting release of personal health information

Exclusion Criteria:

- Patients with a prior or concurrent malignancy whose natural history or treatment does
not have the potential to interfere with the safety or efficacy assessment of the
investigational regimen are eligible for this trial

- Patients may not have received neoadjuvant chemotherapy or radiotherapy for the
treatment of this disease

- Patients may not have received previous hormonal therapy for the treatment of this
disease

- Patients with known hypersensitivity to letrozole or hypersensitivity/intolerance to
carboplatin/paclitaxel therapy

- Patients with severe cardiac disease:

- Myocardial infarction or unstable angina within 6 months prior to registration

- New York Heart Association (NYHA) class II or greater congestive heart failure

- Patients with known central nervous system metastases

- Patients with active (except for uncomplicated urinary tract infection) or
uncontrolled systemic infection

- Patients with >= grade 2 baseline neuropathy

- Known human immunodeficiency virus (HIV)-infected patients on effective
anti-retroviral therapy with undetectable viral load within 6 months are eligible for
this trial