Letrozole Versus Clomiphene Citrate for Ovulation Induction in Women With Poly Cystic Ovary Syndrome ( PCOS )
Status:
Unknown status
Trial end date:
2016-07-01
Target enrollment:
Participant gender:
Summary
110 infertile women diagnosed as polycystic ovary syndrome (PCOS) at the age group of 20-35
distributed randomly :
- 55 women will receive letrozole 2.5mg twice daily orally from the 2nd day to the 6thday
of the cycle for three successive cycles.
- 55 women will receive clomiphene citrate 50 mg twice daily orally from the 2nd day to
the 6thday of the cycle for three successive cycles.
Patients will be subjected to:
Complete history taking:
1. Details about name, age
2. Menstrual history with determination of menarche
3. Amenorrhea or oligomenorrhea , Regularity of the cycle
4. History of endocrine disease.
5. History of previous operations.
- Physical examination:
- General examination:
With special concern to:
--Acne.
--Hirsutism .
--Weight.
--Height
--BMI was determined :
Wt. in kg ـــــــــــــــــــ =
) Height in m)2
- Abdominal examination :
- for scar of previous pelvic or abdominal operations .
- Pelvic examination :
- vaginal examination for enlarged cystic ovaries.
- ultrasound for diagnosis of pcos.
PARAMETERS:
(1) rate of ovulation (primary parameter). (2) serum progesterone level on day 21. (3) number
of mature follicles produced per cycle. (4) mean endometrial thickness. (6) chemical
pregnancy. (7) ongoing pregnancy