Letrozole Pretreatment With Misoprostol for Second-Trimester Medical Abortion

• Status: Completed
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

To compare the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of pregnancy in second trimester abortion.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams University
• Treatments: Letrozole; Misoprostol

Criteria

Inclusion Criteria:

• Maternal age more than 18 years old (age of legal consent).

• Gestational age between 12 weeks and 24 weeks.

• Hemoglobin >10 g/dL.

• BMI between 25 kg/m2 and 35 kg/m2.

• Miscarriage .

• Living fetus with multiple congenital malformations incompatible with life.

• PPROMs with drained liquor and parents are consenting for termination of pregnancy.

Exclusion Criteria:

• Maternal age less than 18 years old.

• Gestational age less than 12 weeks or more than 24 weeks.

• Hemoglobin <10 g/dL.

• Scared uterus (previous myomectomy, cesarean section, hysterectomy and ruptured uterus).

• Polyhydraminos.

• Anencephaly.

• Fibroid uterus.

• BMI less than 25kg/m2 and more than 35kg/m2.

• Coagulopathy.

• History or evidence of adrenal pathology.

• Previous attempts for induction of abortion in the current pregnancy.