Letrozole Pretreatment With Misoprostol fInduction of Abortion In First-Trimester Missed Miscarriage

• Status: Unknown status
• Trial end date: 2018-12-10
• Target enrollment: 0
• Participant gender: Female

Summary

This study compares the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first trimester pregnancy.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams Maternity Hospital
• Treatments: Letrozole; Misoprostol

Criteria

Inclusion Criteria:

• Gestational age less than 64 days gestation (<9 wks).

• Hemoglobin >10 g/dL.

• BMI between 18.5 kg/m2 and 25 kg/m2.

• Missed abortion.

Exclusion Criteria:

• Molar pregnancy.

• Fibroid uterus.

• Uterine anomalies.

• Coagulopathy.

• Medical disorder that contraindicate induction of abortion (e.g. heart failure).

• Previous attempts for induction of abortion in the current pregnancy.

• Allergy to misoprostol or letrozole.