Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma
Status:
Recruiting
Trial end date:
2028-11-30
Target enrollment:
Participant gender:
Summary
This phase III trial studies how well lenalidomide and dexamethasone works with or without
daratumumab in treating patients with high-risk smoldering myeloma. Drugs used in
chemotherapy, such as lenalidomide and dexamethasone, work in different ways to stop the
growth of tumor cells, either by killing the cells, by stopping them from dividing, or by
stopping them from spreading. Immunotherapy with monoclonal antibodies, such as daratumumab,
may induce changes in the body's immune system and may interfere with the ability of tumor
cells to grow and spread. Giving lenalidomide and dexamethasone with daratumumab may work
better in treating patients with smoldering myeloma.